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IchsC57BL/6J
QTL Variant Detail
Nomenclature
QTL variant: IchsC57BL/6J
Name: immediate cutaneous hypersensitivity QTL; C57BL/6J
MGI ID: MGI:2156447
QTL: Ichs  Location: Chr6:107795610-107795846 bp  Genetic Position: Chr6, cM position of peak correlated region/allele: 49.71 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers susceptibility to immediate cutaneous hypersensitivity (ICHS) compared to A/J. (J:63737)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:63737

(C57BL/6J x A/J)F1 mice were backcrossed to C57BL/6JOlaHsd mice and the offspring were immunized with birch pollen extract in an effort to scan for loci responsible for immediate cutaneous hypersensitivity. Mapping progentiors A/J and C57BL/6J are low and high responders respectively. 89 offspring were informative to show an association of the hypersensitivity phenotype (symbol Ichs) with D6Mit105 with a LOD score of 2.5.

References
Original:  J:63737 Daser A, et al., Genetics of atopy in a mouse model: polymorphism of the IL-5 receptor alpha chain. Immunogenetics. 2000 Jul;51(8-9):632-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory