About   Help   FAQ
QTL Variant Detail
QTL variant: Pabr1C57BL/6J
Name: plasma apolipoprotein B (human) regulator 1; C57BL/6J
MGI ID: MGI:2156396
QTL: Pabr1  Location: Chr6:103777444-136423692 bp  Genetic Position: Chr6, cM position of peak correlated region/allele: 53.05 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Strain of Specimen:  C57BL/6J
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased plasma apoB levels compared to 129X1/SvJ. (J:69759)
Inheritance:    Codominant
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
There is evidence of epistasis between Pabr1 and Pabr2.

Mapping and Phenotype information for this QTL, its variants and associated markers


Three separate crosses [(B6HuBTg x 129)F2 (HuBTg=human apoB transgene on mouse Chromosome 10), N2B6 backcross, and N2/129 backcross] were used to map QTLs involved in plasma apoB levels in male and female mice 8 and 12 weeks of age. Plasma apoB levels are significantly lower in 129/Sv animals and F1 HuBTg animals compared to C57BL/6J. Pabr1 was mapped to chromosomes 6 with a peak LOD score at D6Mit55 (LOD = 14-16, depending on age) and appears to be inherited in a codominant fashion in males (129/Sv allele dominant in females). Pabr1 spans 8.8 cM from D6Mit64 to D6Mit339. Positional candidate genes in the region (Sec13r, Pparg, and Apobec1) were examined and yielded negative results. There is evidence of epistasis between Pabr1 and another mapped locus,Pabr2, on mouse Chromosome 4.

Original:  J:69759 Ko C, et al., Two novel quantitative trait loci on mouse chromosomes 6 and 4 independently and synergistically regulate plasma apoB levels. J Lipid Res. 2001 May;42(5):844-55
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.16
The Jackson Laboratory