Lmb2^MRL/MpScr
QTL Variant Detail

Summary

• QTL variant: Lmb2^MRL/MpScr
• Name: lupus in MRL and B6 F2 cross, QTL 2; MRL/MpScr
• MGI ID: MGI:2156221
• QTL: Lmb2 Location: Chr5:37581488-112465722 bp Genetic Position: Chr5, Syntenic

Variant origin

• Strain of Specimen: MRL-Fas^lpr

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers susceptibility to splenomegaly, lymphadenopathy, and anti-dsDNA antibody production compared to C57BL/6. (J:45708)
• Inheritance: Other (see notes)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Notes

This allele is consistent with a dominant or additive mode of inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:45708

In a (MRL-Tnfrsf6^lpr x C57BL/6-Tnfrsf6^lpr)F1 cross involving 274 F2 progeny a quantitative trait locus, Lmb2, identifying lymphadenopathy and/or splenomegaly was significantly associated with a region of mouse Chromosome 5 flanked by markers D5Mit13 and D5Mit24. The highest LOD scores were associated with D5Mit356.

References

• Original: J:45708 Vidal S, et al., Loci predisposing to autoimmunity in MRL-Fas lpr and C57BL/6-Faslpr mice. J Clin Invest. 1998 Feb 1;101(3):696-702
• All: 2 reference(s)