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Targeted Allele Detail
Symbol: Adam3tm1Ihgg
Name: a disintegrin and metallopeptidase domain 3 (cyritestin); targeted mutation 1, Institut fur Humangenetik
MGI ID: MGI:2156166
Synonyms: Cyrn -
Gene: Adam3  Location: Chr8:24677225-24725852 bp, - strand  Genetic Position: Chr8, 13.09 cM, cytoband A2
Germline Transmission:  Earliest citation of germline transmission: J:58730
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA genomic fragment containing exon 3 was replaced with a neomycin selection cassette in opposite transcriptional orientation to the gene. RT-PCR analysis detected the presence of a trancript that spliced exon 2 to 4, but this mutation introduces a frameshift and premature stop codon. Western blots on testicular extracts confirmed the absence of the full length protein in homozygous mice. (J:58730)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adam3 Mutation:  25 strains or lines available
Original:  J:58730 Shamsadin R, et al., Male mice deficient for germ-cell cyritestin are infertile. Biol Reprod. 1999 Dec;61(6):1445-51
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.10
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