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Targeted Allele Detail
Symbol: Acvrl1tm1Enl
Name: activin A receptor, type II-like 1; targeted mutation 1, En Li
MGI ID: MGI:2155980
Synonyms: Acvrl1-, ALK1-, Alk1neo
Gene: Acvrl1  Location: Chr15:101128522-101145336 bp, + strand  Genetic Position: Chr15, 56.41 cM, cytoband F3
Abnormal yolk sac and embryo morphology of Acvrl1tm1Enl/Acvrl1tm1Enl mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:61177
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
    A PGK-neomycin selection cassette was inserted into exon 8, which encodes kinase subdomain V. (J:61177)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Acvrl1 Mutation:  1 strain or line available
Original:  J:61177 Oh SP, et al., Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis. Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2626-31
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.21
The Jackson Laboratory