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QTL Variant Detail
QTL variant: Estq1C57BL/6J
Name: estradiol regulated response QTL 1; C57BL/6J
MGI ID: MGI:2155975
QTL: Estq1  Location: unknown  Genetic Position: Chr4, cM position of peak correlated region/allele: 22.38 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Strain of Specimen:  C57BL/6J
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased leukocyte infiltration compared to C3H/HeJ. (J:53494)
Inheritance:    Not Specified
View phenotypes and curated references for all genotypes (concatenated display).
Estq1 participates in interactions with Estq4.

Mapping and Phenotype information for this QTL, its variants and associated markers


Significant strain differences in several of the estradiol-regulated uterotropic responses have been observed suggesting that they may be genetically controlled. In this study, the authors chacterized the nature of the major leukocyte infiltrates in the uteri of adult ovariectomized, estradiol-treated mice. C57Bl/6J and (C57BL/6J x C3H/HeJ)F1 mice responded with greater numbers of infiltrating eosinophils and BM8+ macrophages as compared with C3H/HeJ mice. In contrast estradiol treatment either down-regulates or does not affect the number of CD4+ or Ia+ cells in the uteri of all three strains. Genome exculsion mapping using a [(C57BL/6J x C3H/HeJ)F1 x C3H/HeJ} backcross was carried out to map the loci controling the number of infiltrating eosinophils into the uterus. Significant linkage was observed with the markers D4Mit237 (t score = 4.06 P = 0.00005) , D4Mit183 (t score = 4.06, P = 0.00005) and D4Mit21 (t score = 3.89, P = 0.00009). This locus has been designated as Estq1. The highest number of infiltrating eosinophils were seen with mice having the C57BL/6J allele at D4Mit237 and D10Mit180 but are homozygous for C3H/HeJ at D16Mit144.

Original:  J:53494 Griffith JS, et al., Evidence for the genetic control of estradiol-regulated responses. Implications for variation in normal and pathological hormone-dependent phenotypes. Am J Pathol. 1997 Jun;150(6):2223-30
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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