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QTL Variant Detail
QTL variant: Tlsr3C57BL/6J
Name: thymic lymphoma suppressor region 3; C57BL/6J
MGI ID: MGI:2155974
QTL: Tlsr3  Location: Chr4:129572018-137137225 bp  Genetic Position: Chr4, Syntenic
Strain of Specimen:  C57BL/6J
Allele Type:    QTL
Inheritance:    Not Specified

Mapping and Phenotype information for this QTL, its variants and associated markers


Primary thymic lymphomas induced by gamma rays in (C57BL/6J x BALB/cJ)F1 mice and (BALB/cJ x C57BL/6J)F1 mice were examined for allelic loss using a number of mouse Chromosome 4 markers. The Tlsr2 tumor suppressor region mapping was centered at D4Mit205b.

10.20.2015_djr Curator Note: Because Tlsr2 was originally mapped in J:31797 in 1996 using

(C57BL/6J x RF/J)F1 mice, which differ from the population used here, we consider the current study a separate mapping experiment and have named this QTL Tlsr10.

A new critical region/quantitative trait locus involved in thymic lymphomagenesis, Tlsr3, was placed between D4Mit203 and D4Mit68.

Original:  J:49558 Santos J, et al., A new candidate site for a tumor suppressor gene involved in mouse thymic lymphomagenesis is located on the distal part of chromosome 4. Oncogene. 1998 Aug 20;17(7):925-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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