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Targeted Allele Detail
Symbol: Acetm1Mcf
Name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; targeted mutation 1, Mark C Fishman
MGI ID: MGI:2155955
Gene: Ace  Location: Chr11:105967945-105989964 bp, + strand  Genetic Position: Chr11, 68.84 cM
Germline Transmission:  Earliest citation of germline transmission: J:32114
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutation:    Not Specified
Mutation detailsThe authors mutated the gene to eliminate expression from the somatic promoter of the gene while preserving expression from the testicular promoter. Specific construct details were not available. Homozygous mutant mice lack the protein in all tissues except the testes. (J:32114)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ace Mutation:  5 strains or lines available
The Acetm1Mcf mouse may serve as useful model system to study the progression of the nephronophthisis-uremic medullary cystic disease complex, a group of disorders that cause renal failure and are characterized by medullary cysts, corticotubular atrophy, interstitial inflammation, water wasting and uremia.
Original:  J:32114 Carpenter C, et al., Renal abnormalities in mutant mice [letter]. Nature. 1996 28;380(6572):292
All:  1 reference(s)

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MGI 6.13
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