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Targeted Allele Detail
Symbol: Acetm1Keb
Name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; targeted mutation 1, Kenneth E Bernstein
MGI ID: MGI:2155954
Synonyms: ACE.1 KO, ACE-KO
Gene: Ace  Location: Chr11:105967945-105989964 bp, + strand  Genetic Position: Chr11, 68.84 cM
Germline Transmission:  Earliest citation of germline transmission: J:33018
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Modified isoform(s), Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced part of intron 12 and part of the testis-specific exon. These sequences included the testis specific promoter and the testis specific translational start site. Expression of the somatic isoform of the protein is also disrupted. Protein activity assays confirmed the absence of functional protein in serum, lung, kidney and testis in homozygous mice. (J:33018)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 14 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ace Mutation:  5 strains or lines available
Original:  J:33018 Esther CR Jr, et al., Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility. Lab Invest. 1996 May;74(5):953-65
All:  12 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.13
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