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Targeted Allele Detail
Symbol: Abcc9tm1Cfb
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 9; targeted mutation 1, Charles F Burant
MGI ID: MGI:2155916
Synonyms: Sur2 -
Gene: Abcc9  Location: Chr6:142587862-142702274 bp, - strand  Genetic Position: Chr6, 74.35 cM
Germline Transmission:  Earliest citation of germline transmission: J:71840
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Duplication, Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced sequences encoding the first ATP binding domain and a transmembrane domain. An additional integration event 3' to the gene caused a duplication of the gene between exons 9 to 27. Northern blot analysis indicated that no transcript was detectable from this allele in RNA derived from heart or skeletal muscle in homozygous mice. No protein activity was detected in cardiac myocytes or in skeletal muscle of homozygous mice. (J:71840)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Abcc9 Mutation:  4 strains or lines available
Phenotypic Similarity to Human Syndrome: Prinzmetal or variant angina (J:78066)

Original:  J:71840 Chutkow WA, et al., Disruption of Sur2-containing KATP channels enhances insulin-stimulated glucose uptake in skeletal muscle. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11760-4
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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