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Abcc1tm1Bor
Targeted Allele Detail
Nomenclature
Symbol: Abcc1tm1Bor
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 1; targeted mutation 1, Piet Borst
MGI ID: MGI:2155908
Synonyms: mrp-, mrp1-, MRP1-
Gene: Abcc1  Location: Chr16:14361558-14475737 bp, + strand  Genetic Position: Chr16, 9.75 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:44110
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA hygromycin selection cassette replaced sequences encoding the first ATP binding domain. No full length or truncated protein was detected in western blots on extracts derived from a variety of tissues from homozygous mice. (J:44110)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Abcc1 Mutation:  7 strains or lines available
References
Original:  J:44110 Wijnholds J, et al., Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein. Nat Med. 1997 Nov;3(11):1275-9
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/24/2015
MGI 5.21
The Jackson Laboratory