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Gjb3tm1Kwi
Targeted Allele Detail
Nomenclature
Symbol: Gjb3tm1Kwi
Name: gap junction protein, beta 3; targeted mutation 1, Klaus Willecke
MGI ID: MGI:2155738
Synonyms: connexin31-
Gene: Gjb3  Location: Chr4:127325235-127330844 bp, - strand  Genetic Position: Chr4, 61.48 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:68014
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA promoterless lacZ gene without a nuclear localization signal and neomycin resistance cassette were inserted immediately downstream of the start codon. Beta-galactosidase is expressed from this allele in a pattern similar to the endogenous gene. (J:68014)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 8 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gjb3 Mutation:  97 strains or lines available
References
Original:  J:68014 Plum A, et al., Connexin31-deficiency in mice causes transient placental dysmorphogenesis but does not impair hearing and skin differentiation. Dev Biol. 2001 Mar 15;231(2):334-47
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory