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QTL Variant Detail
QTL variant: Athsq1MOLF/Ei
Name: atherosclerosis susceptibility QTL 1; MOLF/Ei
MGI ID: MGI:2155675
QTL: Athsq1  Location: Chr4:137617848-151654550 bp  Genetic Position: Chr4, cM position of peak correlated region/allele: 70.02 cM
QTL Note: genome coordinates based on the boundaries of the QTL region
Strain of Specimen:  MOLF/EiJ
Allele Type:    QTL
Mutation:    Undefined
    This allele confers susceptibility to atherosclerosis in female animals compared to C57BL/6J. (J:70259)
Inheritance:    Dominant
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures

Trait Annotation
(using the Vertebrate Trait Ontology)

organ system trait
circulatory system morphology trait
blood vessel morphology trait
aorta integrity trait - VT:0010602
aortic root lesion size is increased relative to C57BL/6J in female mice only - J:70259

Mapping and Phenotype information for this QTL, its variants and associated markers


174 (MOLF/Ei x B6.129S7-Ldlrtm1Her) x C57BL/6J-Ldlrtm1Her backcross animals were used in a mapping study to identify QTLs affecting atheroscerlosis susceptibility. Ldlr knockout animals develop elevated plasma LDL levels and larger atherosclerotic lesions in response to Western-style diet compared to non-knockout animals. Two novel QTLs, Athsq1 and Athsq2, affecting lesion size were mapped to mouse Chromosomes 4 and 6 respectively. Athsq1 (LOD = 6.2 at D4Mit127) maps to a locus spanning D4Mit54 (66 cM) - D4Mit42 (81 cM) on Chromosome 4. MOLF/Ei alleles at Athsq1 confer dominant susceptibility to atherosclerosis (i.e., increased mean lesion size) in female mice. Mice inheriting susceptibility alleles at both loci exhibit 2-fold increase in mean lesion size, indicating an additive effect for Athsq1 and Athsq2. Two-way ANOVA analysis revealed no evidence of interactions between Athsq1 and Athsq2. Other phenotypes associated with atherosclerosis susceptibility (plasma total cholesterol, HDL cholesterol, non-HDL cholesterol, triglycerides, insulin, and body weight) did not show linkage to Athsq1 or Athsq2.

Original:  J:70259 Welch CL, et al., Localization of atherosclerosis susceptibility loci to chromosomes 4 and 6 using the Ldlr knockout mouse model. Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):7946-51
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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