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Targeted Allele Detail
Symbol: Chrna3tm1Bay
Name: cholinergic receptor, nicotinic, alpha polypeptide 3; targeted mutation 1, Baylor College of Medicine
MGI ID: MGI:2155602
Synonyms: alpha3 -
Gene: Chrna3  Location: Chr9:55010117-55026562 bp, - strand  Genetic Position: Chr9, 29.84 cM
Phenotypic findings of Chrna3tm1Bay/Chrna3tm1Bay mice.

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:54994
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 1.8kb genomic fragment containing exon 3 was replaced by an HPRT minigene. These sequences encode three of the four transmembrane domains, the amphipathic helix domain and the four cysteines essential for ligand binding. No transcript produced from this allele was detectable by northern blotting. (J:54994)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Chrna3 Mutation:  23 strains or lines available
Original:  J:54994 Xu W, et al., Megacystis, mydriasis, and ion channel defect in mice lacking the alpha3 neuronal nicotinic acetylcholine receptor. Proc Natl Acad Sci U S A. 1999 May 11;96(10):5746-51
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory