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Chrm5tm1Jwe
Targeted Allele Detail
Nomenclature
Symbol: Chrm5tm1Jwe
Name: cholinergic receptor, muscarinic 5; targeted mutation 1, Jurgen Wess
MGI ID: MGI:2155599
Synonyms: M5R -
Gene: Chrm5  Location: Chr2:112479171-112480769 bp, - strand  Genetic Position: Chr2, 57.02 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:72953
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA genomic fragment containing sequences encoding the first 250 amino acids of the protein was replaced with a neomycin resistance cassette. RT-PCR analysis demonstrated that the transcript was not detectable in RNA derived from tissues of homozygous mice. (J:72953)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Chrm5 Mutation:  26 strains or lines available
References
Original:  J:72953 Yamada M, et al., Cholinergic dilation of cerebral blood vessels is abolished in M(5) muscarinic acetylcholine receptor knockout mice. Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):14096-101
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory