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Targeted Allele Detail
Symbol: Tfebtm1Est
Name: transcription factor EB; targeted mutation 1, Eirikur Steingrimsson
MGI ID: MGI:2155473
Synonyms: TfebFcr
Gene: Tfeb  Location: Chr17:47737030-47792419 bp, + strand  Genetic Position: Chr17, 23.99 cM, cytoband D
Germline Transmission:  Earliest citation of germline transmission: J:50513
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 4kb genomic fragment containing sequences encoding the bHLH-Zip domains was replaced by a neomycin resistance cassette in the opposite transcriptional orientation. RT-PCR analysis indicated that a truncated transcript is produced from this allele, but no active protein is predicted to be produced. (J:50513)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tfeb Mutation:  31 strains or lines available
Original:  J:50513 Steingrimsson E, et al., The bHLH-Zip transcription factor Tfeb is essential for placental vascularization. Development. 1998 Dec;125(23):4607-16
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.04
The Jackson Laboratory