Tfeb^tm1Est
Targeted Allele Detail

Summary

• Symbol: Tfeb^tm1Est
• Name: transcription factor EB; targeted mutation 1, Eirikur Steingrimsson
• MGI ID: MGI:2155473
• Synonyms: Tfeb^Fcr
• Gene: Tfeb Location: Chr17:48047962-48103341 bp, + strand Genetic Position: Chr17, 23.99 cM, cytoband D
• Alliance: Tfeb^tm1Est page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50513
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 4kb genomic fragment containing sequences encoding the bHLH-Zip domains was replaced by a neomycin resistance cassette in the opposite transcriptional orientation. RT-PCR analysis indicated that a truncated transcript is produced from this allele, but no active protein is predicted to be produced. (J:50513)

Expression

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tfeb Mutation: 45 strains or lines available

References

• Original: J:50513 Steingrimsson E, et al., The bHLH-Zip transcription factor Tfeb is essential for placental vascularization. Development. 1998 Dec;125(23):4607-16
• All: 2 reference(s)