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Mdfitm1Krt
Targeted Allele Detail
Nomenclature
Symbol: Mdfitm1Krt
Name: MyoD family inhibitor; targeted mutation 1, Norbert Kraut
MGI ID: MGI:2155446
Synonyms: I-mfa null
Gene: Mdfi  Location: Chr17:47815328-47834691 bp, - strand  Genetic Position: Chr17, 23.99 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:50877
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced exon 5 coding sequences, corresponding to amino acids 162-246 required for protein-protein interactions with MyoD family members. Northern blot and RT-PCR analysis on RNA derived from E14.5 embryos demonstrated that no stable transcript was produced from this allele. (J:50877)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mdfi Mutation:  11 strains or lines available
References
Original:  J:50877 Kraut N, et al., Requirement of the mouse I-mfa gene for placental development and skeletal patterning. EMBO J. 1998 Nov 2;17(21):6276-88
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory