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Hsf1tm1Ijb
Targeted Allele Detail
Nomenclature
Symbol: Hsf1tm1Ijb
Name: heat shock factor 1; targeted mutation 1, Ivor J Benjamin
MGI ID: MGI:2155444
Synonyms: Hsf1-
Gene: Hsf1  Location: Chr15:76477445-76500972 bp, + strand  Genetic Position: Chr15, 35.95 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:73593
Parent Cell Line:  KG-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 1.8kb genomic fragment containing all or part of 6 exons was replaced by a neomycin resistance cassette. These sequences encode half the DNA binding domain and the adjacent oligomerization domain of the protein. Northern blot analysis on RNA derived from homozygous embryonic cells demonstated that a mutant, truncated transcript was produced from this allele. However, western blot analysis indicated that no protein was detectable in cells derived from homozygous embryos. (J:73593)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 78 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hsf1 Mutation:  7 strains or lines available
References
Original:  J:73593 McMillan DR, et al., Targeted disruption of heat shock transcription factor 1 abolishes thermotolerance and protection against heat-inducible apoptosis. J Biol Chem. 1998 Mar 27;273(13):7523-8
All:  42 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory