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Myo7a4626SB
Chemically induced Allele Detail
Nomenclature
Symbol: Myo7a4626SB
Name: myosin VIIA; shaker 4626SB
MGI ID: MGI:2155422
Synonyms: Myo7ash1-5R, sh14626SB, sh1OR-4626SB, shaker-1
Gene: Myo7a  Location: Chr7:98051060-98119524 bp, - strand  Genetic Position: Chr7, 53.57 cM
Cochlear hair cell abnormalities in Myo7aHdb/Myo7a+, Myo7aHdb/Myo7a+ Myo7a4626SB/Myo7a+, and Myo7ash1/Myo7ash1 mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  BALB/cRl
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsA C-to-T transition mutation is predicted to result in a glycine to stop codon change at position 720 in the encoded protein. This mutation is predicted to lie within the head domain of the protein. Northern blot analysis indicated that mRNA expression, size, and stability were unaffected. Immunoblot analysis showed that less than 1% of the normal level of the protein was expressed. (J:49926)
Inheritance:    Recessive
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 1 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Myo7a Mutation:  34 strains or lines available
References
Original:  J:54592 Rinchik EM, et al., N-ethyl-N-nitrosourea mutagenesis of a 6- to 11-cM subregion of the Fah-Hbb interval of mouse chromosome 7: Completed testing of 4557 gametes and deletion mapping and complementation analysis of 31 mutations. Genetics. 1999 May;152(1):373-83
All:  24 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory