Bomb1^NSF/N
QTL Variant Detail

Summary

• QTL variant: Bomb1^NSF/N
• Name: bone marrow pre-B 1; NSF/N
• MGI ID: MGI:2155343
• QTL: Bomb1 Location: Chr3:128133243-128133417 bp Genetic Position: Chr3, cM position of peak correlated region/allele: 56.89 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: NFS/N

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers lymphoma resistance compared to SL/Kh. (J:55364)
• Inheritance: Other (see notes)

Notes

Bomb1 exhibits an additive mode of inheritance. This allele increases pre-B cell percentages.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:55364

SL/Kh inbred mice exhibit a high incidence of pre-B lymphomas and an abnormal transient expression of bone marrow pre-B-1 cells, whereas NFS/N mice have a low incidence of spontaneous lymphoma and a low number of bone marrow pre-B-1 cells. F2 and backcross populations of mice derived from crosses betweeb SL/Kh and NFS/N mice were informative in mapping a QTL to mouse Chromosome 3 with a peak LOD (10.7) at marker D3Mit319. A gene within the QTL region that may be a candidate for the Bomb1 phenotype is suggested to be Lef1.

References

• Original: J:55364 Lu LM, et al., Bone marrow pre-B-1 (Bomb1): a quantitative trait locus inducing bone marrow pre-B-cell expansion in lymphoma-prone SL/Kh mice. Cancer Res. 1999 Jun 1;59(11):2593-5
• All: 2 reference(s)