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QTL Variant Detail
QTL variant: Obq3C57L/J
Name: obesity QTL 3; C57L/J
MGI ID: MGI:2155174
QTL: Obq3  Location: unknown  Genetic Position: Chr2, cM position of peak correlated region/allele: 50.66 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Strain of Specimen:  C57L/J
Allele Type:    QTL
Inheritance:    Other (see notes)
Obq3 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers


Statistical analysis of 93 individual genotypes (up to 339 for select markers) from (AKR/J x C57L/J)F2 fat and lean pool mice indicated the presence of a QTL locus on mouse Chromosome 2 affecting the adiposity index. A LOD peak score of 5.1 occurred at aposition 2 cM distal to D2Mit15. A broad 1-LOD support interval extending from ~6 cM distal to D2Mit237 to ~3.0 cM proximal to D2Mit168 was found to be consistant with either a one or two gene model. Gene order and percentage of recombination between markers is reported as: D2Mit296 - 2.8 - D2Mit237 - 20.4 - D2Mit66 - 0.8 - D2Mit15 - 9.1 - D2Mit62 - 10.7 - D2Mit168 - 20.3 - D2Mit311. This QTL is reported to account for 7.0% of the phenotype variance.

Original:  J:39947 Taylor BA, et al., Obesity QTLs on mouse chromosomes 2 and 17. Genomics. 1997 Aug 1;43(3):249-57
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.19
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