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Obq3C57L/J
QTL Variant Detail
Nomenclature
QTL variant: Obq3C57L/J
Name: obesity QTL 3; C57L/J
MGI ID: MGI:2155174
QTL: Obq3  Location: unknown  Genetic Position: Chr2, cM position of peak correlated region/allele: 50.66 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  C57L/J
Variant
description
Allele Type:    QTL
Inheritance:    Other (see notes)
Notes
Obq3 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:39947

Statistical analysis of 93 individual genotypes (up to 339 for select markers) from (AKR/J x C57L/J)F2 fat and lean pool mice indicated the presence of a QTL locus on mouse Chromosome 2 affecting the adiposity index. A LOD peak score of 5.1 occurred at aposition 2 cM distal to D2Mit15. A broad 1-LOD support interval extending from ~6 cM distal to D2Mit237 to ~3.0 cM proximal to D2Mit168 was found to be consistant with either a one or two gene model. Gene order and percentage of recombination between markers is reported as: D2Mit296 - 2.8 - D2Mit237 - 20.4 - D2Mit66 - 0.8 - D2Mit15 - 9.1 - D2Mit62 - 10.7 - D2Mit168 - 20.3 - D2Mit311. This QTL is reported to account for 7.0% of the phenotype variance.

References
Original:  J:39947 Taylor BA, et al., Obesity QTLs on mouse chromosomes 2 and 17. Genomics. 1997 Aug 1;43(3):249-57
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory