About   Help   FAQ
Due to maintenance, access to MGI may be intermittent 8:00 AM ET Wed, September 18.
Obq3AKR/J
QTL Variant Detail
Nomenclature
QTL variant: Obq3AKR/J
Name: obesity QTL 3; AKR/J
MGI ID: MGI:2155173
QTL: Obq3  Location: unknown  Genetic Position: Chr2, cM position of peak correlated region/allele: 50.66 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  AKR/J
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased adiposity in male animals compared to C57L/J. (J:39947)
Inheritance:    Other (see notes)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Notes
Obq3 exhibits an additive mode of inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:39947

Statistical analysis of 93 individual genotypes (up to 339 for select markers) from (AKR/J x C57L/J)F2 fat and lean pool mice indicated the presence of a QTL locus on mouse Chromosome 2 affecting the adiposity index. A LOD peak score of 5.1 occurred at aposition 2 cM distal to D2Mit15. A broad 1-LOD support interval extending from ~6 cM distal to D2Mit237 to ~3.0 cM proximal to D2Mit168 was found to be consistant with either a one or two gene model. Gene order and percentage of recombination between markers is reported as: D2Mit296 - 2.8 - D2Mit237 - 20.4 - D2Mit66 - 0.8 - D2Mit15 - 9.1 - D2Mit62 - 10.7 - D2Mit168 - 20.3 - D2Mit311. This QTL is reported to account for 7.0% of the phenotype variance.

References
Original:  J:39947 Taylor BA, et al., Obesity QTLs on mouse chromosomes 2 and 17. Genomics. 1997 Aug 1;43(3):249-57
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/10/2019
MGI 6.14
The Jackson Laboratory