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QTL Variant Detail
QTL variant: Mobq5C57BL/6J
Name: multigenic obesity QTL 5; C57BL/6J
MGI ID: MGI:2155131
QTL: Mobq5  Location: Chr2:65439402-162677006 bp  Genetic Position: Chr2, cM position of peak correlated region/allele: 38.54 cM
QTL Note: genome coordinates based on the boundaries of the QTL region
Strain of Specimen:  C57BL/6J
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased adiposity compared to CAST/Ei.
Inheritance:    Codominant
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures

Mapping and Phenotype information for this QTL, its variants and associated markers


Over 200 (C57BL/6J x CAST/Ei)F2 intercross animals were typed for 116 polymorphic markers on all mouse chromosomes (except the Y chromosome) at an average marker density of 10 cM to identify QTLs associated with body fat. Inbred parental strain CAST/Ei is very lean (~8% body fat) compared to inbred parental strain C57BL/6J (~18% body fat). (CAST/Ei x C57BL/6J)F1 hybrids exhibit an intermediate phenotype. Mob5 (multigenic obesity) mapped to distal Chromosome 2 from approximately 75 cM - 109 cM with a peak LOD = 5.8 near D2Mit50. Mob5 is also linked to QTL peaks for hepatic lipase activity, HDL cholesterol levels on chow diet, and insulin levels. Mob6 mapped to central mouse Chromosome 2 from approximately 35 cM - 85 cM with a peak LOD = 7.4 near D2Mit14a. Mob6 is also linked to QTL peaks for hepatic lipase activity, HDL cholesterol levels on atherogenic diet, and insulin levels. Mob7 mapped to proximal mouse Chromosome 2 from approximately 25 cM - 35 cM with a peak LOD = 5.8 near D2Mit9. Mob7 is also linked to QTL peaks for HDL levels on atherogenic diet and insulin levels. Mob8 mapped to mouse Chromosome 9 with a peak LOD = 4.7 at D9Mit8. A suggestive QTL for body fat mapped to mouse Chromosome 8 with peak LOD = 3.2 near D8Mit12. Mob5, Mob6, and Mob7 appear to affect body fat inheritance in a codominant fashion with CAST-derived alleles conferring reduction in body fat. In contrast, Mob8 appears to be dominantly inherited with CAST-derived alleles conferring increased body fat. Candidate genes in the region of Mob5 and Mob6 are Mc3r, Tnfrsf5 (Cd40), Cebpb, Pltp, agouti, Ghrh, Ahcy, Pcsk2, Adra2b, Scg5, Lrp2 (Gp330), and a candidate gene in the region of Mob7 is Ptgds. Candidate genes in the region of Mob8 include Ldlr, Il10ra, Apoa1, Apoa4, Apoc3, Acat1, Cyp11a1, and Lipc (Hlp). A QTL associated with body length and body weight, Bdln2, mapped to mouse Chromosome 15 from 7.8 cM - 10.6 cM with a maximum LOD = 4.3 at D15Mit54. A candidate gene near Bldn2 is Ghr, growth hormone receptor.

Original:  J:48038 Mehrabian M, et al., Genetic loci controlling body fat, lipoprotein metabolism, and insulin levels in a multifactorial mouse model. J Clin Invest. 1998 Jun 1;101(11):2485-96
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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