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EtohrC57BL/6J
QTL Variant Detail
Nomenclature
QTL variant: EtohrC57BL/6J
Name: ethanol response acute; C57BL/6J
MGI ID: MGI:2155093
QTL: Etohr  Location: Chr2:80175610-80175769 bp  Genetic Position: Chr2, cM position of peak correlated region/allele: 47.93 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Mutation:    Undefined
 
Mutation detailsThis allele confers decreased locomotor activity in response to alcohol challenge compared to DBA/2J. (J:52042)
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:52042

Changes in locomotor activity due to ethanol was analysed in BXD RI stains and in 900 F2 (C57BL/6J x DBA/2J) intercross mice. The RI data provided a suggestive association of the locomotor response with markers on various chromosomes including mouse Chromosome 2. The mouse Chromosome 2 location was verified in the F2 cross and reached a level of significance when combined with the RI data. The activity QTL (Etohr) on mouse chromosome 2 had a peak LOD of 5.3 with an approximate cM position of 48 and was associated with markers D2Mit94 and D2Mit420.

References
Original:  J:52042 Demarest K, et al., Identification of an acute ethanol response quantitative trait locus on mouse chromosome 2. J Neurosci. 1999 Jan 15;19(2):549-61
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory