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Bglu1C57BL/6Slc
QTL Variant Detail
Summary
QTL variant: Bglu1C57BL/6Slc
Name: blood glucose level 1; C57BL/6Slc
MGI ID: MGI:2154951
QTL: Bglu1  Location: Chr2:117942930-174324863 bp  Genetic Position: Chr2, cM position of peak correlated region/allele: 59.34 cM
QTL Note: genome coordinates based on the boundaries of the QTL region
Variant
origin
Strain of Specimen:  C57BL/6Slc
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased blood glucose levels compared to C3H/HeSlc. (J:62933)
Inheritance:    Dominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:62933

Inbred strain C57BL/6Scl secretes less insulin and exhibits higher blood glucose levels than inbred strain C3H/HeSlc when subject to an intraperitoneal glucose tolerance test (IPGTT). A pooling strategy was used to identify QTLs associated with glucose intolerance in a population of (C3H/HeSlc x C57BL/6Slc)F2 male animals. 30 F2 males with the highest 30-minute glucose values and 30 F2 males with the lowest 30-minute glucose values were typed for 87 polymorphic markers spanning the 19 autosomes. Significant loci were confirmed by screening (using the same set of markers) a population of 59 F3 male animals generated from crossing F2 animals with the highest (high x high) and lowest (low x low) glucose values. A locus on mouse Chromosome 2, Bglu1, is significantly associated with blood glucose levels. Bglu1 gave a LOD score of 8.3 at D2Mit48 and has a QTL range from 65 cM - 105 cM defined by D2Mit62 and D2Mit265. C57BL/6Slc-derived alleles appear to have a dominant effect in increasing blood glucose levelsat Bglu1. Candidate genes in the region of Bglu1 include Chgb, Pcsk2, A (agouti), Kcnb1, and Hnf4a. A second locus associated with blood glucose levels, Bglu2, mapped to mouse Chromosome 13 giving a LOD score of 4.2 at D13Mit148 with a QTL range from 59 cM- 61 cM defined by D13Mit148 and D13Mit76. C57BL/6Slc-derived alleles appear to influence blood glucose levels in a codominant fashion at Bglu2. Candidate genes in the region of Bglu2 include Pcsk1 and Pik3r1. Direct sequencing of Pcsk1 and Pcsk2 did notreveal polymorphisms or mutations in C57BL/6Scl or C3H/HeSlc parental inbred strains.

References
Original:  J:62933 Kayo T, et al., Identification of two chromosomal loci determining glucose intolerance in a C57BL/6 mouse strain. Comp Med. 2000 Jun;50(3):296-302
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory