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Sgcgtm1Mcn
Targeted Allele Detail
Nomenclature
Symbol: Sgcgtm1Mcn
Name: sarcoglycan, gamma (dystrophin-associated glycoprotein); targeted mutation 1, Elizabeth M McNally
MGI ID: MGI:2154693
Synonyms: gsg -
Gene: Sgcg  Location: Chr14:61221059-61258490 bp, - strand  Genetic Position: Chr14, 32.27 cM, cytoband C3
Stunted growth and abnormal stance in Sgcgtm1Mcn/Sgcgtm1Mcn mice

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:49871
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance gene replaced exon 2, which encodes the initiation codon, the cytoplasmic tail and the transmembrane domain of the encoded protein. (J:49871)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sgcg Mutation:  1 strain or line available
References
Original:  J:49871 Hack AA, et al., Gamma-sarcoglycan deficiency leads to muscle membrane defects and apoptosis independent of dystrophin. J Cell Biol. 1998 Sep 7;142(5):1279-87
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/10/2018
MGI 6.12
The Jackson Laboratory