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Cyp1b1tm1Gonz
Targeted Allele Detail
Nomenclature
Symbol: Cyp1b1tm1Gonz
Name: cytochrome P450, family 1, subfamily b, polypeptide 1; targeted mutation 1, Frank J Gonzalez
MGI ID: MGI:2154690
Synonyms: cyp1b1-
Gene: Cyp1b1  Location: Chr17:79706940-79715061 bp, - strand  Genetic Position: Chr17, 50.3 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:53827
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
    A neomycin selection cassette was inserted into coding sequences in exon 3. (J:53827)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Cyp1b1 Mutation:  17 strains or lines available
References
Original:  J:53827 Buters JT, et al., Cytochrome P450 CYP1B1 determines susceptibility to 7, 12-dimethylbenz[a]anthracene-induced lymphomas. Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):1977-82
All:  37 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory