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Sgcbtm1Oza
Targeted Allele Detail
Nomenclature
Symbol: Sgcbtm1Oza
Name: sarcoglycan, beta (dystrophin-associated glycoprotein); targeted mutation 1, Eijiro Ozawa
MGI ID: MGI:2154611
Synonyms: BSG -
Gene: Sgcb  Location: Chr5:73632749-73647731 bp, - strand  Genetic Position: Chr5, 38.89 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:57590
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced a genomic fragment containing exon 2. Northern blot analysis demonstrated that the transcript was not detectable in total RNA derived from skeletal muscle of homozygous mice, and western blot analysis confirmed that the protein was not detectable in microsomal preparations of skeletal muscle of homozygous mice. (J:57590)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sgcb Mutation:  6 strains or lines available
References
Original:  J:57590 Araishi K, et al., Loss of the sarcoglycan complex and sarcospan leads to muscular dystrophy in beta-sarcoglycan-deficient mice. Hum Mol Genet. 1999 Sep;8(9):1589-98
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory