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Lama3tm1Crt
Targeted Allele Detail
Nomenclature
Symbol: Lama3tm1Crt
Name: laminin, alpha 3; targeted mutation 1, William G Carter
MGI ID: MGI:2154553
Synonyms: alpha3-
Gene: Lama3  Location: Chr18:12333819-12583013 bp, + strand  Genetic Position: Chr18, 6.2 cM, cytoband A
Progressive blistering and reduced milk content in the stomach of Lama3tm1Crt/Lama3tm1Crt mice

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:55865
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced a genomic fragment containing exon A3. This exon encodes sequences common to both isoforms of the protein. Removal of this exon is predicted to cause a frameshift mutation and result in premature termination of the protein. Immunohistochemistry analysis on skin derived from homozygous mice confirmed that the protein was not detectable. (J:55865)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lama3 Mutation:  125 strains or lines available
References
Original:  J:55865 Ryan MC, et al., Targeted disruption of the LAMA3 gene in mice reveals abnormalities in survival and late stage differentiation of epithelial cells. J Cell Biol. 1999 Jun 14;145(6):1309-23
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory