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Targeted Allele Detail
Symbol: Aplp1tm1Umu
Name: amyloid beta (A4) precursor-like protein 1; targeted mutation 1, Ulrike Muller
MGI ID: MGI:2154545
Synonyms: APLP1-
Gene: Aplp1  Location: Chr7:30434982-30445535 bp, - strand  Genetic Position: Chr7, 18.32 cM
Germline Transmission:  Earliest citation of germline transmission: J:65196
Parent Cell Line:  GS1 (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced an ~8kb segment of the gene, comprising 2.5kb of the putative promoter, the first exon containing the ATG translational start codon, and genomic sequences containing ~50% of the coding region of the gene. Northern and Western blots of brain tissue from homozygous mutant mice showed no detectable transcript and protein, respectively. (J:65196)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aplp1 Mutation:  15 strains or lines available
Original:  J:65196 Heber S, et al., Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members. J Neurosci. 2000 Nov 1;20(21):7951-63
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory