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Itgb1tm2Ref
Targeted Allele Detail
Nomenclature
Symbol: Itgb1tm2Ref
Name: integrin beta 1 (fibronectin receptor beta); targeted mutation 2, Reinhard Fassler
MGI ID: MGI:2154538
Synonyms: beta1-, beta1neo
Gene: Itgb1  Location: Chr8:128685654-128733200 bp, + strand  Genetic Position: Chr8, 76.09 cM, cytoband E2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:28330
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA promoterless neomycin resistance gene was inserted in-frame to the ATG of the gene. Northern blot analysis demonstrated that no transcript was produced from this allele. (J:28330)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itgb1 Mutation:  13 strains or lines available
References
Original:  J:28330 Fassler R, et al., Consequences of lack of beta 1 integrin gene expression in mice. Genes Dev. 1995 Aug 1;9(15):1896-908
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory