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Targeted Allele Detail
Symbol: Cyp19a1tm1Esi
Name: cytochrome P450, family 19, subfamily a, polypeptide 1; targeted mutation 1, Evan R Simpson
MGI ID: MGI:2154536
Synonyms: ArKO
Gene: Cyp19a1  Location: Chr9:54165937-54193442 bp, - strand  Genetic Position: Chr9, 29.49 cM
Increased adipocyte size in Cyp19a1tm1Esi/Cyp19a1tm1Esi mice

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:48086
Parent Cell Line:  KG-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsInsertion of a neomycin resistance cassette into exon 9 disrupted the gene. Aromatase activity was not detected in ovaries of 12 week old homozygous mutant mice. (J:48086)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cyp19a1 Mutation:  11 strains or lines available
Phenotypic Similarity to Human Syndrome: Metabolic Syndrome in mice homozygous for Apoetm1Unc and Cyp19a1tm1Esi (J:184647)

Original:  J:48086 Fisher CR, et al., Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp19 gene. Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6965-70
All:  51 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.21
The Jackson Laboratory