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Targeted Allele Detail
Symbol: Thbs1tm1Hyn
Name: thrombospondin 1; targeted mutation 1, Richard Hynes
MGI ID: MGI:2154534
Synonyms: tbsp1-, Thbs1-, TSP-1, TSP-1-, TSP1-, Tsp-1KO
Gene: Thbs1  Location: Chr2:118111876-118127133 bp, + strand  Genetic Position: Chr2, 59.34 cM, cytoband F1-F3
Lordotic curvature of the spine in Thbs1tm1Hyn/Thbs1tm1Hyn mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:46182
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced exon 2, intron 3, and exon 3. An RNase protection assay demonstrated that no detectable transcript was present in multiple tissues of homozygous animals. Western analysis confirmed the absence of the encoded protein. (J:46182)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 27 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Thbs1 Mutation:  40 strains or lines available
Original:  J:46182 Lawler J, et al., Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia. J Clin Invest. 1998 Mar 1;101(5):982-92
All:  115 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory