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Cdk4tm1.1Bbd
Targeted Allele Detail
Nomenclature
Symbol: Cdk4tm1.1Bbd
Name: cyclin-dependent kinase 4; targeted mutation 1.1, Mariano Barbacid
MGI ID: MGI:2154521
Synonyms: Cdk4R, Cdk4R24C, Cdk4 R24C
Gene: Cdk4  Location: Chr10:127063535-127067288 bp, + strand  Genetic Position: Chr10, 74.5 cM, cytoband D3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:54534
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsThis allele is a derivative of Cdk4tm1Bbd in which the neomycin resistance cassette was deleted via Cre-mediated recombination in the germ line. These mice express comparable levels of mutant protein to wild-type levels. (J:54534)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdk4 Mutation:  30 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Melanoma (J:189221)
References
Original:  J:54534 Rane SG, et al., Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia. Nat Genet. 1999 May;22(1):44-52
All:  41 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/12/2019
MGI 6.13
The Jackson Laboratory