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Targeted Allele Detail
Symbol: Pthlhtm1Hmk
Name: parathyroid hormone-like peptide; targeted mutation 1, Henry M Kronenberg
MGI ID: MGI:2154515
Synonyms: PTHrP-
Gene: Pthlh  Location: Chr6:147252109-147264013 bp, - strand  Genetic Position: Chr6, 78.19 cM, cytoband F-G
Alizarin red S stained skeletal images of hemizygous and homozygous Tg(Col2a1-PTHR1*H223R)AHju and Pthlhtm1Hmk/Pthlhtm1Hmk mice

Show the 10 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:16911
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced 1.2 kb of sequence including exon IV, which contains most of the coding region. (J:16911)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 17 assay results
In Structures Affected by this Mutation: 31 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pthlh Mutation:  17 strains or lines available
Original:  J:16911 Karaplis AC, et al., Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene. Genes Dev. 1994 Feb 1;8(3):277-89
All:  45 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory