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QTL Variant Detail
QTL variant: Cia23NOD/ShiLtJ
Name: collagen induced arthritis QTL 23; NOD/ShiLtJ
MGI ID: MGI:2154513
Synonyms: Cia23NOD
QTL: Cia23  Location: Chr2:12124726-66726109 bp  Genetic Position: Chr2, Syntenic
Strain of Specimen:  NOD/ShiLtJ
Allele Type:    QTL
Inheritance:    Other (see notes)
View phenotypes and curated references for all genotypes (concatenated display).
Cia23 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers


353 (NOD.Q-H2q x B10.Q-H2q)F2 animals were screened for 155 polymorphic markers at an average spacing of 8.6 cM to identify loci associated with collagen induced arthritis. The NOD.Q-H2q congenic is resistant to collagen induced arthritis compared to the B10.Q-H2q congenic which develops arthritis of intermediate severity at an incidence of 50% following injection with type 2 collagen. (NOD.Q-H2q x B10.Q-H2q)F1 animals are resistant to arthritis.

A novel QTL for arthritis severity, Cia9, mapped to mouse Chromosome 1 from 81.6 cM - 106.3 cM with a peak LOD score = 5.6 at the Fcgr2b gene.

NOD.Q-H2q-derived alleles at Cia9 contribute to additively inherited disease susceptibility.

A locus associated with arthritis severity and C5 serum levels, Cia23, mapped to mouse Chromosome 2 from 11 cM - 37 cM with a peak LOD score = 9.8 at the Hc (C5) gene. B10.Q-H2qderived alleles at Cia23 contribute to additively inherited susceptibility to disease.

Cia23 and Cia9 show evidence of interaction: resistance to arthritis depends upon heterozygosity at Cia23 and homozygosity for B10.Q-H2qderived alleles at Cia9. This interaction was confirmed using speed congenic strains carrying a NOD.Q-H2q-derived allele at Cia23 on a B10.Q-H2q background.

10.21.2014 Curator's Note: The authors refer to the Chromosome 2 QTL identified here as Cia2. However, because Cia2 was orginally mapped using a DBA/1J x SWR/J cross in J:53356 (1991) we consider the current study a separate mapping experiment and have named this QTL Cia23.

Original:  J:69981 Johansson AC, et al., Genetic control of collagen-induced arthritis in a cross with NOD and C57BL/10 mice is dependent on gene regions encoding complement factor 5 and FcgammaRIIb and is not associated with loci controlling diabetes. Eur J Immunol. 2001 Jun;31(6):1847-56
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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