About   Help   FAQ
Bdt1C57BL/6J
QTL Variant Detail
Nomenclature
QTL variant: Bdt1C57BL/6J
Name: bone density traits 1; C57BL/6J
MGI ID: MGI:2154510
QTL: Bdt1  Location: Chr2:167146982-167147098 bp  Genetic Position: Chr2, cM position of peak correlated region/allele: 87.22 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Inheritance:    Not Specified
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:69682

Genome scan at an average marker spacing of 13 cM was performed on female animals from a (C57BL/6J x DBA/2J)F2 intercross to identify QTLs associated with bone density and bone density related traits. Animals were placed on a 16 week atherogenic diet at 12 months of age. QTLs were identified on mouse Chromosome 2 spanning 90 cM - 130 cM (Bdt1, LOD = 5.65 at D2Mit413), mouse Chromosome 3 spanning 40 cM - 70 cM (Bdt2, LOD = 8.09 at D3Mit14), mouse Chromosome 6 spanning 60 cM - 85 cM (Bdt3, LOD = 6.4 at D6Mit198), mouse Chromosome 7 spanning 0 cM - 50 cM (Bdt4, LOD = 8.28 at D7Mit80), and mouse Chromosome 15 spanning 0 cM - 30 cM (Bdt5, LOD = 6.13 at D15Mit13) and spanning 20 cM - 50 cM (Bdt6, LOD = 7.73 at D15Mit206). ANOVA analysis detected interaction between Bdt3 on Chromosome 6 and Bdt5 on Chromosome 15. Bdt1, Bdt2, and Bdt3 colocalize with QTLs for nonbone traits and may indicate pleiotropic effects at these loci. Further investigation concluded Bdt2 is distinct from colocalizing loci for body length and HDL cholesterol, but did not rule out pleiotropy at Bdt1 for adipose mass and HDL cholesterol and at Bdt2 for plasma HDL and subcutaneous fat pad mass.

References
Original:  J:69682 Drake TA, et al., Genetic loci determining bone density in mice with diet-induced atherosclerosis. Physiol Genomics. 2001 Apr 27;5(4):205-15
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/23/2021
MGI 6.16
The Jackson Laboratory