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Stia2C57BL/6J
QTL Variant Detail
Summary
QTL variant: Stia2C57BL/6J
Name: serum transfer induced arthritis 2; C57BL/6J
MGI ID: MGI:2154506
QTL: Stia2  Location: Chr2:34873343-34951450 bp  Genetic Position: Chr2, Syntenic
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased arthritis severity compared to NOD/LtDOI. (J:70882)
Inheritance:    Dominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:70882

132 animals from a (C57BL/6J x NOD/LtDOI)F2 intercross were typed for 162 microsatellite markers at an average spacing of 7.84 cM to identify QTLs associated with susceptibility to rheumatoid arthritis. (C57BL/6J x NOD/LtDOI)F2 animals were inoculated with serum from K/BXN T cell receptor transgenic mice to induce arthritis. Parental strain C57BL/6J is susceptible to serum transfer induced arthritis whereas NOD/LtDOI is resistant. Stia1 (serum transfer induced arthritis 1) maps to 81.6 cM on mouse Chromosome 1 with a LOD score of 4.5 at D1Mit33. The Stia1 interval spans 79 cM - 92. cM. Stia2 maps to 23.5 cM on mouse Chromosome 2 with a LOD score of 7 at the Hc (hemolytic complement) locus. The Stia2 locus spans 11 cM - 41.4 cM. Hc is a possible candidategene for Stia2 because Hc appears to be required to develop arthritis via serum transfer, and Hc is known to be defective in the NOD/LtDOI strain.

References
Original:  J:70882 Ji H, et al., Genetic influences on the end-stage effector phase of arthritis. J Exp Med. 2001 Aug 6;194(3):321-30
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory