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Targeted Allele Detail
Symbol: Bcrtm1Hkp
Name: BCR activator of RhoGEF and GTPase; targeted mutation 1, Nora Heisterkamp
MGI ID: MGI:2154396
Gene: Bcr  Location: Chr10:75060592-75184921 bp, + strand  Genetic Position: Chr10, 38.49 cM
Germline Transmission:  Earliest citation of germline transmission: J:23804
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 2 was partially replaced by insertion of a neomycin resistance expression cassette. Northern blot analysis with an exon 1 specific probe demonstrated that the transcript was not expressed in brain of homozygous mice, and western blot analysis on brain extracts showed that no protein was produced in homozygotes. (J:23804, J:199684)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Bcr Mutation:  5 strains or lines available
Original:  J:23804 Voncken JW, et al., Increased neutrophil respiratory burst in bcr-null mutants. Cell. 1995 Mar 10;80(5):719-28
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory