About   Help   FAQ
Bcrtm1Hkp
Targeted Allele Detail
Summary
Symbol: Bcrtm1Hkp
Name: BCR activator of RhoGEF and GTPase; targeted mutation 1, Nora Heisterkamp
MGI ID: MGI:2154396
Gene: Bcr  Location: Chr10:74896424-75020753 bp, + strand  Genetic Position: Chr10, 38.49 cM
Alliance: Bcrtm1Hkp page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:23804
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 was partially replaced by insertion of a neomycin resistance expression cassette. Northern blot analysis with an exon 1 specific probe demonstrated that the transcript was not expressed in brain of homozygous mice, and western blot analysis on brain extracts showed that no protein was produced in homozygotes. (J:23804, J:199684)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Bcr Mutation:  51 strains or lines available
References
Original:  J:23804 Voncken JW, et al., Increased neutrophil respiratory burst in bcr-null mutants. Cell. 1995 Mar 10;80(5):719-28
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory