Sst1^C3HeB/FeJ
QTL Variant Detail

Summary

• QTL variant: Sst1^C3HeB/FeJ
• Name: susceptibility to tuberculosis 1; C3HeB/FeJ
• MGI ID: MGI:2154340
• QTL: Sst1 Location: Chr1:81652114-87130822 bp Genetic Position: Chr1, cM position of peak correlated region/allele: 44.07 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C3HeB/FeJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers tuberculosis susceptibility compared to C57BL/6J. (J:63410)
• Inheritance: Recessive

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:63410

A total of 368 (C3HeB/FeJ x C57BL/6J)F2 mice were analyzed for resistance and susceptibility to Mycobacterium tuberculosis. A subset of 46 F2 susceptible mice exhibited linkage of the susceptible phenotype (marker symbol Sst1) with D1Mit46 on mouse Chromosome 1. The strongest evidence for linkage was found with D1Mit49. Further analysis of 367 F2 mice showed Sst1 to be located within a 11 cM interval flanked by D1Mit46 and D1Mit187. Moreover fine genetic mapping using F2 and backcross progeny showed Sst1 to be located within a range flanked by markers D1Mit334 and D1Mit45 which included D1Mit49.

References

• Original: J:63410 Kramnik I, et al., Genetic control of resistance to experimental infection with virulent Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8560-5
• All: 11 reference(s)