Cafq1^C3H/HeJ
QTL Variant Detail

Summary

• QTL variant: Cafq1^C3H/HeJ
• Name: caffeine metabolism QTL 1; C3H/HeJ
• MGI ID: MGI:2153926
• QTL: Cafq1 Location: Chr1:172716221-172716369 bp Genetic Position: Chr1, cM position of peak correlated region/allele: 80.33 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C3H/HeJ

Variant description

• Allele Type: QTL
• Inheritance: Other (see notes)

Notes

Cafq1 exhibits additive inheritance and shows stronger association in males.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:68139

QTL mapping was performed on 438 F2 animals from an intercross between the acetaminophen nonsusceptible (APN) strain and C3H/HeJ to identify loci associated with caffeine metabolism. The average spacing between markers is 13 cM. Caffeine metabolism QTLs mapped to mouse Chromosome 1 (Cafq1), mouse Chromosome 4 (Cafq2), and mouse Chromosome 9 (Cafq3). Cafq1 is located 85 cM - 95.8 cM on mouse Chromosome 1 with a peak LOD = 9.7 at D1Mit356. No obvious candidate genes are found near Cafq1. Males show a stronger association to the phenotype than females at this locus. Cafq2 is located 31.4 cM - 57 cM on mouse Chromosome 4 with a peak LOD = 3.4 at D4Mit199. Cafq3 is located 28 cM - 48 cM on mouse Chromosome 9 with a peak LOD = 25 at D9Mit248 and D9Mit21. Cyp1a2 is a likely positional candidate gene for Cafq3 based on its known role in caffeine metabolism and differences in protein and mRNA expression of Cyp1a2 between the parental strains.

References

• Original: J:68139 Casley WL, et al., Detection of quantitative trait loci affecting caffeine metabolism by interval mapping in a genome-wide scan of C3H/HeJ x APN F(2) mice. Drug Metab Dispos. 1999 Dec;27(12):1375-80
• All: 1 reference(s)