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Rxratm4.1Ipc
Targeted Allele Detail
Nomenclature
Symbol: Rxratm4.1Ipc
Name: retinoid X receptor alpha; targeted mutation 4.1, Pierre Chambon
MGI ID: MGI:2153829
Synonyms: RxralphaL-
Gene: Rxra  Location: Chr2:27676440-27762957 bp, + strand  Genetic Position: Chr2, 19.38 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:67149
Parent Cell Line:  P1 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThis allele is a derivative of Rxratm4Ipc in which exon 4 and flanking sequences including the thymidine kinase/ neomycin resistance cassette were removed in the germ line by crossing Rxratm4Ipc mice with transgenic mice expressing Cre recombinase under the control of a CMV promoter. (J:67149)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rxra Mutation:  15 strains or lines available
References
Original:  J:67149 Li M, et al., RXR-alpha ablation in skin keratinocytes results in alopecia and epidermal alterations. Development. 2001 Mar;128(5):675-88
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory