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Rxratm4Ipc
Targeted Allele Detail
Nomenclature
Symbol: Rxratm4Ipc
Name: retinoid X receptor alpha; targeted mutation 4, Pierre Chambon
MGI ID: MGI:2153828
Synonyms: RxralphaL2
Gene: Rxra  Location: Chr2:27676440-27762957 bp, + strand  Genetic Position: Chr2, 19.38 cM
Rxratm4Ipc/Rxratm4Ipc Rxrbtm1Pcn/Rxrbtm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0 mice develop a chronic skin inflammation

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:65109
Parent Cell Line:  P1 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted 3' to exon 4 and an thymidine kinase/ neomycin resistance expression cassette followed by an additional loxP site was inserted 5' to exon 4. (J:67149)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rxra Mutation:  6 strains or lines available
References
Original:  J:65109 Li M, et al., Skin abnormalities generated by temporally controlled RXRalpha mutations in mouse epidermis. Nature. 2000 Oct 5;407(6804):633-6
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory