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Targeted Allele Detail
Symbol: Fgfr2tm2.3Dsn
Name: fibroblast growth factor receptor 2; targeted mutation 2.3, Clive Dickson
MGI ID: MGI:2153817
Synonyms: Fgfr2delta, FgfR2-IIIcdelta
Gene: Fgfr2  Location: Chr7:130162451-133123350 bp, - strand  Genetic Position: Chr7, 73.19 cM
Growth retardation in Fgfr2tm2.3Dsn/Fgfr2+ mice

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:72517
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThis allele is a derivative of Fgfr2tm2Dsn in which both the exon 9 sequences and the neomycin and thymidine kinase sequences were deleted by crossing mice carrying the Fgfr2tm2Dsn allele to mice which expresss Cre recombinase in the germ line. (J:72517)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgfr2 Mutation:  52 strains or lines available
Original:  J:72517 Hajihosseini MK, et al., A splicing switch and gain-of-function mutation in FgfR2-IIIc hemizygotes causes Apert/Pfeiffer-syndrome-like phenotypes. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3855-60
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory