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Targeted Allele Detail
Symbol: Fgfr2tm2Dsn
Name: fibroblast growth factor receptor 2; targeted mutation 2, Clive Dickson
MGI ID: MGI:2153813
Synonyms: FgfR2-IIIcneo-flox
Gene: Fgfr2  Location: Chr7:130162451-130266944 bp, - strand  Genetic Position: Chr7, 73.19 cM
Submandibular gland is hypoplastic in Fgfr2tm2Dsn/Fgfr2+ Tg(Pgk1-cre)1Lni/0, Fgf10tm1Wss/Fgf10+, and Fgf10tm1Wss/Fgf10+ Fgfr2tm2Dsn/Fgfr2+ Tg(Pgk1-cre)1Lni/0 mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:72517
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP flanked neomycin resistance and thymidine kinase cassette was inserted into intron 8 and a single loxP site was inserted into intron 9. (J:72517)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgfr2 Mutation:  23 strains or lines available
ES cell line was not specified, but described as "129-derived."
Original:  J:72517 Hajihosseini MK, et al., A splicing switch and gain-of-function mutation in FgfR2-IIIc hemizygotes causes Apert/Pfeiffer-syndrome-like phenotypes. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3855-60
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory