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Fgfr1tm1Jrt
Targeted Allele Detail
Nomenclature
Symbol: Fgfr1tm1Jrt
Name: fibroblast growth factor receptor 1; targeted mutation 1, Janet Rossant
MGI ID: MGI:2153342
Synonyms: fgfr-1deltatmk
Gene: Fgfr1  Location: Chr8:25513654-25575714 bp, + strand  Genetic Position: Chr8, 14.12 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:22117
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA genomic fragment containing exons 8-14, which encode the transmembrane and most of the catalytic domain, was replaced by a neomycin resistance cassette. (J:22117)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fgfr1 Mutation:  172 strains or lines available
References
Original:  J:22117 Yamaguchi TP, et al., fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation. Genes Dev. 1994 Dec 15;8(24):3032-44
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/25/2015
MGI 5.21
The Jackson Laboratory