Fgfr1^tm1Jrt
Targeted Allele Detail

Summary

• Symbol: Fgfr1^tm1Jrt
• Name: fibroblast growth factor receptor 1; targeted mutation 1, Janet Rossant
• MGI ID: MGI:2153342
• Synonyms: fgfr-1^deltatmk
• Gene: Fgfr1 Location: Chr8:26008808-26067819 bp, + strand Genetic Position: Chr8, 14.12 cM
• Alliance: Fgfr1^tm1Jrt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:22117
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing exons 8-14, which encode the transmembrane and most of the catalytic domain, was replaced by a neomycin resistance cassette. (J:22117)

Expression

In Mice Carrying this Mutation:	21 assay results
In Structures Affected by this Mutation:	29 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgfr1 Mutation: 221 strains or lines available

References

• Original: J:22117 Yamaguchi TP, et al., fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation. Genes Dev. 1994 Dec 15;8(24):3032-44
• All: 12 reference(s)