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Cspg4tm1Wbst
Targeted Allele Detail
Nomenclature
Symbol: Cspg4tm1Wbst
Name: chondroitin sulfate proteoglycan 4; targeted mutation 1, William B Stallcup
MGI ID: MGI:2153094
Synonyms: NG2-
Gene: Cspg4  Location: Chr9:56865104-56899870 bp, + strand  Genetic Position: Chr9, 30.32 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:54319
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance cassette was inserted into exon 3. Western blot analysis of P4 brain extracts using a rabbit antibody did not detect protein in homozygous mutant mice. Immunohistochemical studies of aortic smooth muscle cells did not detect protein in P1 homozygous mutant mice. (J:54319)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cspg4 Mutation:  37 strains or lines available
References
Original:  J:54319 Grako KA, et al., PDGF (alpha)-receptor is unresponsive to PDGF-AA in aortic smooth muscle cells from the NG2 knockout mouse. J Cell Sci. 1999 Mar;112(Pt 6):905-15
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory