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Targeted Allele Detail
Symbol: Sparcl1tm1Pmc
Name: SPARC-like 1; targeted mutation 1, Peter J McKinnon
MGI ID: MGI:2153047
Synonyms: hevin null
Gene: Sparcl1  Location: Chr5:104079111-104113733 bp, - strand  Genetic Position: Chr5, 50.55 cM, cytoband E4
Abnormal Purkinje cell morphology in the Sparcl1tm1Pmc/Sparcl1tm1Pmc and Adamts4tm1Dqp/Adamts4tm1Dqp cerebellum

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:59207
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin cassette replaced exon 2, which encodes the secretion signal sequence. RNAse protection assays demonstrated an absence of transcript in RNA derived from cerebellum of adult homozygous mice. Western blot and immunohistochemical analysis did not detect the protein in brain of homozygous mice. (J:59207)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sparcl1 Mutation:  4 strains or lines available
Original:  J:59207 McKinnon PJ, et al., Extracellular matrix-associated protein Sc1 is not essential for mouse development. Mol Cell Biol. 2000 Jan;20(2):656-60
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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