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Matn1tm1Goe
Targeted Allele Detail
Nomenclature
Symbol: Matn1tm1Goe
Name: matrilin 1, cartilage matrix protein; targeted mutation 1, Paul F Goetinck
MGI ID: MGI:2153042
Synonyms: mat-1tm1Goe, Matn1-
Gene: Matn1  Location: Chr4:130944385-130955475 bp, + strand  Genetic Position: Chr4, 64.09 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:58843
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin cassette replaced exon 4 and part of exon 5. In situ hybridization and immunohistochemical analysis in distal growth plates of E15 homozygous embryos demonstrated an absence of transcript and protein. (J:58843)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 5 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Matn1 Mutation:  9 strains or lines available
References
Original:  J:58843 Huang X, et al., Mice lacking matrilin-1 (cartilage matrix protein) have alterations in type II collagen fibrillogenesis and fibril organization. Dev Dyn. 1999 Dec;216(4-5):434-41
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/21/2017
MGI 6.08
The Jackson Laboratory