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Lumtm1Chak
Targeted Allele Detail
Nomenclature
Symbol: Lumtm1Chak
Name: lumican; targeted mutation 1, Shukti Chakravarti
MGI ID: MGI:2153008
Synonyms: Lum-, lumtm1Sc
Gene: Lum  Location: Chr10:97565501-97572703 bp, + strand  Genetic Position: Chr10, 50.32 cM
Fmodtm1Aol/Fmodtm1Aol Lumtm1Chak/Lumtm1Chak mice display decreased body size, abnormal gait and abnormal limb morphology

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:48068
Parent Cell Line:  CT129 (ES Cell)
Strain of Origin:  129S/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    A neomycin resistance cassette replaced 3kb of sequence containing exon 2. (J:48068)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lum Mutation:  3 strains or lines available
Notes
ES cell line = CT 120#25.

References
Original:  J:48068 Chakravarti S, et al., Lumican regulates collagen fibril assembly: skin fragility and corneal opacity in the absence of lumican. J Cell Biol. 1998 Jun 1;141(5):1277-86
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory